The MeCP2 Antibody (N-term S80) from MyBioSource.com is a Rabbit Polyclonal antibody to MECP2, methyl-CpG binding protein 2, PPMX, and RTT. This antibody recognizes Human, Mouse, and Rat antigen. The MeCP2 Antibody (N-term S80) has been validated for the following applications: ELISA, Flow Cytometry, Immunohistochemistry, and Western Blot.
Description
DNA methylation is the major modification of eukaryotic
genomes and plays an essential role in mammalian development. Human
proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of
nuclear proteins related by the presence in each of a methyl-CpG
binding domain (MBD). Each of these proteins, with the exception of
MBD3, is capable of binding specifically to methylated DNA. MECP2,
MBD1 and MBD2 can also repress transcription from methylated gene
promoters. In contrast to other MBD family members, MECP2 is
X-linked and subject to X inactivation. MECP2 is dispensible in
stem cells, but is essential for embryonic development. MECP2 gene
mutations are the cause of most cases of Rett syndrome, a
progressive neurologic developmental disorder and one of the most
common causes of mental retardation in females. [provided by
RefSeq]